Sibutramin Hydroklorit determination (HPLC)

Determination of Sibutramine Hydrochloride (HPLC)
Determination of Sibutramine Hydrochloride (HPLC)

Sibutramine is a medicine that is used to lose weight or to maintain weight, or to treat obesity. In drugs this substance is used in the form of sibutramine hydrochloride monohydrate.

It is generally recommended to use sibutramine hydrochloride in combination with a low-calorie diet. This medication is effective if there are other risk factors such as high blood pressure, sugar and dyslipidemia in diseases with a body mass index above 30.

If excessive sibutramine hydrochloride is taken into the body, the heartbeat becomes irregular, there is difficulty in breathing, headache and dizziness, sleep disorders and symptoms of depression.

Recently, it was decided that the risks of using sibutramine-containing drugs outweigh the benefits in European countries and it was proposed to stop the sale of these drugs. In our country, the licenses of these drugs were canceled in 2011 and it was announced that the sale was stopped by being recalled from the market. However, there are products on the market that are claimed to be completely herbal and effective in weight loss. Laboratory studies have shown that the risk of heart disease caused by sibutramine in such herbal products is greater than the expected benefit when used for weight loss.

As an active ingredient, sibutramine is included in the content of supplements and similar products or products introduced to the market within the scope of herbal teas. Hydrochloride should be avoided. Especially herbal products containing sibutramine will be completely withdrawn from the market. Because these kinds of herbal drugs that are said to lose weight put people's health at risk.

Determination of sibutramine hydrochloride is performed in authorized laboratories. In these studies, high performance liquid chromatography method (HPLC) is applied which provides higher phase moving at higher pressure and separation at higher resolution. It also complies with current legal regulations and published standards and analysis methods.