paralytic Shellfish Poison group (PSP) (LC-MS / MS)

Paralytic Shellfish Poison Group (PSP) (LC-MS / MS)
Paralytic Shellfish Poison Group (PSP) (LC-MS / MS)

Paralytic seafood poisoning (Paralytic Shellfish Poison, PSP) is a disease that occurs in humans by consuming mussels, oysters, scallops and similar shellfish that are fed with poisonous dinophilagellates. These toxins mostly cause discomfort in the stomach and intestines and nervous system. Toxin accumulates in the digestive systems and soft tissues of bivalve species, which are considered to be fed with algae containing PSP, and poisoning occurs in humans fed with this seafood.

Paralytic Shellfish Poison (PSP) responsible dinophilagellates are extremely resistant to acid and heat and produce 12 type of toxin. These toxins are very strong water-soluble poisons. Even 1 mg of these toxins is able to lead a person to death.

The group of paralytic aquatic poisons forms different 20 forms. It is mainly divided into three basic groups: carbamate toxins, sulfocarbamyl toxins and decarbamyl toxins. Of these, carbamate toxins are the most toxic. These toxins are gonyatoxin, neosaxitoxin and saxitoxin.

Paralytic aquaculture toxin protogonyalax type There are nine types of dinophilagellates: saxitoxin, neosaxitoxin, gonyatoxin 1, gonyatoxin 2, gonyatoxin 3, gonyatoxin 4, gonyatoxin 5, goniatoxin 6 and gonyatoxin 7. Of these, the most toxic is saxitoxin and gonyatoxin 3.

The analyzes performed under the Paralytic Shellfish Poison Group (PSP) are as follows:

  • Paralytic Shellfish Poison Group (PSP) - Gonyatoxin (GTX)
  • Paralytic Shellfish Poison Group (PSP) - Neosaxitoxin (NEO)
  • Paralytic Shellfish Poison Group (PSP) - Saxitoxin (STX)

In the advanced laboratories, Paralytic Shellfish Poison Group (PSP) intoxication analyzes are performed by LC-MS / MS method within the framework of biotoxin analyzes. The LC-MS / MS method, called liquid chromatography - mass - mass spectrometer, uses the mass analysis capabilities of the mass spectrometer together with the physical separation properties of liquid chromatography. These analyzes are based on standards and test methods published by domestic and foreign organizations.